前言
自觉性遗传模子为研究癫痫全身性爆发，特殊是研究癫痫失神爆发提供了基础。WAG/Rij大鼠用于研究遗传性癫痫失神爆发，其行为学改变、EEG体现（体现为棘慢复合板波）以及遗传特征等方面与人类癫痫失神爆发极为相像，已被普遍用于研究人类癫痫失神爆发。
部分造模要领
使用动物：大鼠
【造�；啤�：
WAG/Rij大鼠泉源于1924年Bacharach培育的远交系Wistar基因突变大鼠。
【模子特点】：
现在常用的失神爆发遗传模子主要为WAG/Rij大鼠，无论是在苏醒或睡眠状态下，均能纪录到双侧同步、阵发性的棘波发放和两侧同步对称的3Hz棘慢波发放(spike and wave discharges,SWDs)，同时伴有临床失神爆发的体现。
【模子评估和应用】：
能显著抑制该模子失神爆发的药物往往对临床失神爆发有用，两者间具有高度相关性。g－氨基丁酸B1激动剂能加重WAG/Rij大鼠模子的SWDs发放。只管上述两种遗传性失神模子具有自觉失神爆发及SWDs，但因难以大宗滋生，从而使其应用受到限制。
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